InVitroCYP H-class™ Microsomes

Liver microsomes provide a readily available and well-characterized biological model for use in CYP enzyme studies. InVitroCYP H-class microsomes are prepared from tissues that are screened and selected for high activity across the panel of nine cytochrome P450 enzymes, including those CYPs that are traditionally low in activity. This microsome classification provides researchers with enhanced sensitivity for inhibition studies or other applications requiring greater activity.

InVitroCYP M-class™ Microsomes

Human liver microsomes are subcellular fractions that contain drug-metabolizing enzymes, including CYP enzymes, flavin monooxygenases and UDP glucuronyl transferases. InVitroCYP M-class microsomes are designed to exhibit average CYP activity, ideal for metabolic studies. Celsis’ extensive characterization and tissue profiling process guarantee that each lot of InVitroCYP M-class microsomes will provide consistent and reproducible results for your metabolic and clearance identification assays.

InVitroCYP C-class™ Microsomes

Because some studies look for specific interactions, InVitroCYP C-class microsomes are designed by you to fit your research criteria. Examples of C-class preparations include:

1. Microsomes prepared for specific donor demographics such as age, gender, race, CMV status, etc.

2. Large lots manufactured to a specific vial configuration.

3. Single donor or pooled microsomes with particularly high or low activity in specific CYP enzymes.

4. Additional enzyme characterization.

Custom preparations are not limited to the above list. For InVitroCYP C-class microsome requests, please contact: IVTSpecials@celsis.com or ask your Celsis representative for more information.